South America's biggest club competition is at an elite level, with Brazilian sides dominating the round of 16. At 321bet you can bet on every match with real-time odds, over 60 markets per game, and Pix withdrawals in as little as 3 minutes.
All Round of 16 matchups with available odds — updated in real time on 321bet
The Copa Libertadores has always been the most electrifying stage in South American football, and the 2026 edition is no exception. Flamengo, Palmeiras, Fluminense, Atlético-MG, Botafogo, Cruzeiro, Grêmio, and São Paulo are all representing Brazil in the Round of 16 — a historic dominance that reflects the growing quality of Brazilian football in recent years.
The 321bet covers every Libertadores match with over 60 markets per game: match result, handicap, over/under goals, both teams to score, corners, cards, first goalscorer, exact score and much more. For the knockout stages, where the tension peaks, qualification markets are also available — such as "who advances to the next round" and "will the match go to extra time or penalties".
Brazilian fans have a special bond with the Libertadores. It unites historic rivals in a common cause — seeing Brazil lift the trophy — and that creates an atmosphere that goes far beyond any domestic league game. When Flamengo took the field against River Plate in the 2019 final in Lima, the whole country stopped. And when Fluminense claimed the title in 2023, beating Boca Juniors at the Maracanã, the Maraca proved it can be the most electrifying stage in the world.
On 321bet, betting on the Libertadores at 321bet is as straightforward as sending a Pix. Deposit from R$ 20.00, navigate to the match you want and build your bet slip. For the biggest Libertadores nights — especially quarterfinals and semifinals — 321bet publishes odds boosts on selected markets, increasing prices by up to 20% on the most anticipated fixtures of the round.
| Market | Sample Odds |
|---|---|
| 1X2 Result | 1.55 / 3.80 / 5.50 |
| Over/Under 2.5 Goals | 1.80 / 2.00 |
| Both Teams to Score | 1.70 (Yes) / 2.10 (No) |
| Asian Handicap | -0.5 / +0.5 |
| First Goalscorer | 4.50 – 9.00 |
| Total Corners | Over/Under 8.5 |
| Correct Score | 1-0: 5.50 |
| Goes to Penalties | 3.20 (Yes) |
| Qualification | Palmeiras to advance: 1.65 |
| Champion | Flamengo: 3.20 |
See how the Brazilian clubs performed in the group stage before advancing to the knockout rounds
| Club | J | V | E | D | Pts |
|---|---|---|---|---|---|
| Flamengo | 6 | 4 | 2 | 0 | 14 |
| Racing | 6 | 3 | 1 | 2 | 10 |
| Aucas | 6 | 1 | 2 | 3 | 5 |
| The Strongest | 6 | 0 | 1 | 5 | 1 |
| Club | J | V | E | D | Pts |
|---|---|---|---|---|---|
| Palmeiras | 6 | 5 | 1 | 0 | 16 |
| Boca Jr | 6 | 3 | 0 | 3 | 9 |
| Independiente | 6 | 1 | 2 | 3 | 5 |
| Alianza Lima | 6 | 0 | 1 | 5 | 1 |
| Club | J | V | E | D | Pts |
|---|---|---|---|---|---|
| Fluminense | 6 | 4 | 1 | 1 | 13 |
| River Plate | 6 | 3 | 2 | 1 | 11 |
| Cerro Porteño | 6 | 1 | 1 | 4 | 4 |
| Sporting Cristal | 6 | 0 | 2 | 4 | 2 |
| Club | J | V | E | D | Pts |
|---|---|---|---|---|---|
| Botafogo | 6 | 3 | 2 | 1 | 11 |
| Peñarol | 6 | 3 | 1 | 2 | 10 |
| Junior | 6 | 2 | 1 | 3 | 7 |
| Universitario | 6 | 0 | 2 | 4 | 2 |
The top two teams in each group advance to the Round of 16. Data shown is for illustrative purposes only.
Betting on the Libertadores comes with a few unique factors that set it apart from domestic football. In the Brasileirão, you know every team inside out — the poor pitches, the most intense home crowds, which manager rotates the squad and when. In the Libertadores, you add a South American layer: Argentine, Uruguayan, Chilean, and Peruvian clubs with different tactical cultures, stadiums at extreme altitude, and histories that most Brazilian bettors don't follow day to day.
Altitude is one of the most underestimated factors in Libertadores betting. When a Brazilian club travels to La Paz, Bolivia — over 3,600 meters above sea level — or even to Quito, Ecuador, the physical toll is real and well-documented. Flamengo has dropped crucial points in these fixtures, and so has Palmeiras. On 321bet, that context is already reflected in the handicap odds and under goal markets, which tend to offer more value in those matches.
In the round of 16 and quarterfinals, the two-legged format completely reshapes betting strategy. A team that lost 1–0 away still holds a financial and psychological edge playing at home in the second leg — but the odds don't always reflect that fairly. Spotting these situations and reading the tie's context is what separates a sharp bettor from someone just betting on autopilot.
The 321bet provides stats for both teams directly on each Libertadores match page: head-to-head history, away goals conceded, form over the last 5 matches, and confirmed absences. All of it available before you place any bet — whether it's a single selection or part of an accumulator.
For the biggest Libertadores matches, 321bet also activates live betting with odds updated minute by minute. If the favorite concedes an unexpected early goal, the comeback odds can shift to attractive levels — and that's exactly when well-prepared bettors find the best value. With Pix available 24 hours a day, depositing and withdrawing at just the right moment has never been faster.
Odds are for illustration only. Check live values at 321bet.
Eight Brazilian clubs in the knockout stage — bet on every matchup at 321bet
Features that make a difference on Libertadores nights — from the group stage to the grand final
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Brazil holds the largest collection of Copa Libertadores titles of any country. With over 20 victories, Brazilian clubs were the central figures in the competition's most thrilling decades — from Santos with Pelé in the 1960s to the dominant modern era of Flamengo, Palmeiras, Fluminense and Botafogo.
Grêmio and São Paulo have each won three titles, cementing their generations as all-time benchmarks. Grêmio under Renato Gaúcho in the 1980s and 90s won with authority, while São Paulo under Telê Santana in the 90s claimed three consecutive Club World Cup titles. More recently, Flamengo, Palmeiras, and Fluminense have shown that Brazilian football has returned to South American elite standards after years of financial hardship in the early 2000s.
The 2019 final between Flamengo and River Plate in Lima went down as one of the greatest comebacks in the competition's history. Trailing 1–0 at the 88th minute, Flamengo scored twice in stoppage time to win 2–1 and claim the title after 38 years. Over 100,000 fans took to the streets of Rio de Janeiro that night. On 321bet, matches like this one show exactly why live betting on the Libertadores is so thrilling — the result can flip completely in a matter of minutes.
The 2023 final, with Fluminense defeating Boca Juniors at the Maracanã, confirmed that Brazilian football remains the dominant force. And 2026 made history with Botafogo — Brazilian and continental champions in the same year, a feat that hadn't happened since Pelé's Santos in the 1960s.
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